Mouse Monoclonal Antibody to GRIA2

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: N/A; FCM: 1/200 - 1/400; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 7A7A3
Isotype: Mouse IgG2b
Immunogen: Purified recombinant fragment of human GRIA2 (AA: 35-175) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 99kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4384
Reference: 1.Histopathology. 2014 Jul;65(1):71-80.2.Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):367-72.

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