Mouse Monoclonal Antibody to CHRNA4

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: N/A; FCM: N/A; IHC: N/A
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 7B4H1
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human CHRNA4 (AA: extra 29-242) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 70kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4402
Reference: 1.Epilepsy Res. 2014 Dec;108(10):1927-31.2.J Pharmacol Exp Ther. 2014 Mar;348(3):410-20.

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