Mouse Monoclonal Antibody to ELANE

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: N/A; FCM: 1/200 - 1/400; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human;Monkey
Clone: 6B6B10
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human ELANE (AA: 140-267) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 28.5kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4481
Reference: 1.Pediatr Blood Cancer. 2015 Dec;62(12):2229-31.2.Hum Mutat. 2013 Jun;34(6):905-14.

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