STAT5B Polyclonal Antibody
STAT5B Polyclonal Antibody

STAT5B Polyclonal Antibody

E-AB-10058

Regular price $399.00 $349.00 You Pay

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:10-1:50
Size: 200 uL
Concentration: 0.4mg/mL
Swissprot: P51692
Gene Accession: BC020868
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human STAT5B
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control:
Cellular Localization: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-stat5b_polyclonal_antibody-30117.html
Manual Link: https://www.elabscience.com/viewpdf-30117-elabscience-E-AB-10058.PDF