TLR7 Polyclonal AntibodyE-AB-10068
Product Type: Antibody
Descritpion: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal transduction
Recommended Dilutions: IHC 1:10-1:50
Size: 200 uL
Gene Accession: BC033651
Immunogen: Recombinant protein of human TLR7
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
Cellular Localization: Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle>phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-tlr7_polyclonal_antibody-30127.html
Manual Link: https://www.elabscience.com/viewpdf-30127-elabscience-E-AB-10068.PDF