APP Polyclonal AntibodyE-AB-10079
Product Type: Antibody
Descritpion: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease.
Research Areas: Cancer, Neuroscience
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: BC004369
Immunogen: Recombinant protein of human APP
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Expressed in all fetal tissues examined with highest levels in brain, kidney, heart and spleen. Weak expression in liver. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra-striate and motor cortices. Expressed in cerebrospinal fluid, and plasma. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Appican is expressed in astrocytes.
Cellular Localization: Cytoskeleton,ciliary rootlet,spindle midzone,Cytosol,Endoplasmic reticulum,endoplasmic reticulum lumen,rough endoplasmic reticulum,smooth endoplasmic reticulum,Endosome,early Endosome,endosome lumen,Extracellular region or secreted,extracellular exosome,extracellular region,extracellular space,high-density lipoprotein particle,intermediate-density lipoprotein particle,Golgi apparatus,Golgi apparatus,Golgi lumen,trans-Golgi network membrane,Nucleus,nuclear envelope lumen,Plasma Membrane,integral component of Plasma Membrane,Other locations:amyloid-beta complex,apical part of cell,astrocyte projection,axon,cell surface,cell-cell junction,clathrin-coated pit,COPII-coated ER to Golgi transport vesicle,cytoplasm,dendritic shaft,dendritic spine,endosome to plasma membrane transport vesicle,growth cone filopodium,growth cone lamellipodium,integral component of membrane,intracellular,lipoprotein particle,main axon,membrane,membrane raft,neuromuscular junction,perinuclear region of cytoplasm,platelet alpha granule lumen,protein complex,receptor complex,synapse,terminal bouton
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-app_polyclonal_antibody-30138.html
Manual Link: https://www.elabscience.com/viewpdf-30138-elabscience-E-AB-10079.PDF