TONSL Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. 
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal transduction
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:100-1:300
Size: 200 uL
Concentration: 0.6mg/mL
Swissprot: Q96HA7
Gene Accession: BC008782
Reactivity: Human
Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human TONSL
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control: Expressed in heart, skeletal muscle and tracheal epithelial cells.
Cellular Localization: Cytoplasm. Nucleus. Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-tonsl_polyclonal_antibody-30147.html
Manual Link: https://www.elabscience.com/viewpdf-30147-elabscience-E-AB-10088.PDF