IL12RB1 Polyclonal AntibodyE-AB-10101
Product Type: Antibody
Descritpion: The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Research Areas: Immunology
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: BC029121
Immunogen: Recombinant protein of human IL12RB1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control:
Cellular Localization: Membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-il12rb1_polyclonal_antibody-30160.html
Manual Link: https://www.elabscience.com/viewpdf-30160-elabscience-E-AB-10101.PDF