ANXA1 Polyclonal AntibodyE-AB-10135
Product Type: Antibody
Descritpion: Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
Research Areas: Cancer, Signal transduction
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Gene Accession: BC001275
Immunogen: Recombinant protein of human ANXA1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 39kDa
Tissue Specificity/Positive Control: Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.
Cellular Localization: Nucleus. Cytoplasm. Cell projection>cilium. Basolateral cell membrane. Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-anxa1_polyclonal_antibody-30192.html
Manual Link: https://www.elabscience.com/viewpdf-30192-elabscience-E-AB-10135.PDF