CK-4 Polyclonal Antibody
CK-4 Polyclonal Antibody

CK-4 Polyclonal Antibody

E-AB-10146

Regular price $399.00 $349.00 You Pay

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Research Areas: Cancer, Signal transduction, Tags & Cell Markers
Applications: WB,IHC,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:5-1:20
Size: 200 uL
Concentration: 0.3mg/mL
Swissprot: P19013
Gene Accession: BC042174
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human KRT4
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 57kDa
Tissue Specificity/Positive Control: Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.
Cellular Localization: Cytoskeleton,intermediate filament,intermediate filament cytoskeleton,keratin filament,Cytosol,Nucleus,Other locations:cell surface
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-ck_4_polyclonal_antibody-30202.html
Manual Link: https://www.elabscience.com/viewpdf-30202-elabscience-E-AB-10146.PDF