Cathepsin B Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.
Research Areas: Cancer, Neuroscience, Signal transduction
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:150-1:500
Size: 200 uL
Concentration: 0.8mg/mL
Swissprot: P07858
Gene Accession: BC010240
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human CTSB
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control:
Cellular Localization: Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-cathepsin_b_polyclonal_antibody-30263.html
Manual Link: https://www.elabscience.com/viewpdf-30263-elabscience-E-AB-10208.PDF