Product Type: Antibody
Descritpion: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:200-1:1000, IHC 1:15-1:50
Size: 200 uL
Gene Accession: BC003065
Immunogen: Recombinant protein of human CDK2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 34kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytoskeleton,centrosome,Cytosol,Endosome,Nucleus,Cajal body,nucleoplasm,nucleus,Other locations:chromosome, telomeric region,condensed chromosome,cyclin A1-CDK2 complex,cyclin A2-CDK2 complex,cyclin E1-CDK2 complex,cyclin E2-CDK2 complex,cyclin-dependent protein kinase holoenzyme complex,cytoplasm,transcription factor complex,X chromosome,Y chromosome
Storage: Store at -20C. Avoid freeze / thaw cycles.