Product Type: Antibody
Descritpion: Cyclin-dependent kinases (CDKs) are serine/threonine kinases that are activated by cyclins and govern eukaryotic cell cycle progression. While CDK5 shares high sequence homology with its family members, it is thought mainly to function in postmitotic neurons to regulate the cytoarchitecture of these cells. Analogous to cyclins, the regulatory subunits p35 and p39 associate with and activate CDK5 despite the lack of sequence homology.
Research Areas: Cancer, Cell Biology, Metabolism, Neuroscience
Recommended Dilutions: WB 1:500-1:2000, IHC 1:25-1:100
Size: 200 uL
Gene Accession: BC005115
Immunogen: Recombinant protein of human CDK5
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 33kDa
Tissue Specificity/Positive Control: Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary.
Cellular Localization: Cytoplasm. Cell projection>lamellipodium. Cell projection>growth cone. In axonal growth cone with extension to the peripheral lamellipodia.
Storage: Store at -20C. Avoid freeze / thaw cycles.