Factor XIIIa Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot.
Research Areas: Cancer, Cardiovascular, Tags & Cell Markers
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Concentration: 0.1mg/mL
Swissprot: P00488
Gene Accession: BC027963
Reactivity: Human,Mouse
Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human F13A1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control:
Cellular Localization: Cytoplasm, Secreted
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-factor_xiiia_polyclonal_antibody-30683.html
Manual Link: https://www.elabscience.com/viewpdf-30683-elabscience-E-AB-10638.PDF