Product Type: Antibody
Descritpion: The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
Research Areas: Cell Biology, Epigenetics and Nuclear Signaling
Recommended Dilutions: IHC 1:15-1:50
Size: 200 uL
Gene Accession: BC000480
Immunogen: Recombinant protein of human NAE1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Ubiquitous in fetal tissues. Expressed throughout the adult brain.
Cellular Localization: Cell membrane. Colocalizes with APP in lipid rafts.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-nae1_polyclonal_antibody-30862.html
Manual Link: https://www.elabscience.com/viewpdf-30862-elabscience-E-AB-10818.PDF