AURKAIP1 Polyclonal AntibodyE-AB-10976
Product Type: Antibody
Descritpion: AKIP (AURKA-interacting protein), also known as AURKAIP1 (aurora kinase A interacting protein 1) or AIP, is a 199 amino acid protein that localizes to the nucleus and is ubiquitously expressed, with highest levels present in testis, heart and skeletal muscle. Interacting specifically with ARK-1 (aurora kinase 1), AKIP functions to induce the proteasomal-dependent degradation of ARK-1, thereby acting as a negative regulator of ARK-1 activity. AKIP is encoded by a gene which maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
Research Areas: Cancer, Cell Biology
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Gene Accession: BC062333
Immunogen: Recombinant protein of human AURKAIP1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 22kDa
Tissue Specificity/Positive Control: Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.
Cellular Localization: Mitochondrion. Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-aurkaip1_polyclonal_antibody-31019.html
Manual Link: https://www.elabscience.com/viewpdf-31019-elabscience-E-AB-10976.PDF