Product Type: Antibody
Descritpion: CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Research Areas: Cancer, Immunology, Stem cells
Recommended Dilutions: WB 1:200-1:1000, IHC 1:25-1:100
Size: 200 uL
Gene Accession: BC028152
Immunogen: Recombinant protein of human CD33
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 40kDa
Tissue Specificity/Positive Control: Monocytic/myeloid lineage cells.
Cellular Localization: Cell membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.