Product Type: Antibody
Descritpion: This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations.
Research Areas: Cell Biology
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Gene Accession: BC010901
Immunogen: Recombinant protein of human CKAP2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.
Cellular Localization: Cytoplasm>cytoskeleton. Cytoplasm>cytoskeleton. Cytoplasm>cytoskeleton>spindle. Cytoplasm>cytoskeleton>spindle pole. Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-ckap2_polyclonal_antibody-31126.html
Manual Link: https://www.elabscience.com/viewpdf-31126-elabscience-E-AB-11085.PDF