Product Type: Antibody
Descritpion: CUEDC2 is involved in ubiquitin- and proteasome-mediated degradation of progesterone receptor and estrogen receptor (ER)-alpha.CUEDC2 reduced PRB protein content and promoted progesterone-induced PRB degradation via the ubiquitin-proteasome pathway.
Research Areas: Epigenetics and Nuclear Signaling, Signal transduction
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Gene Accession: BC000262
Immunogen: Recombinant protein of human CUEDC2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.
Cellular Localization: Cytoplasm. Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-cuedc2_polyclonal_antibody-31152.html
Manual Link: https://www.elabscience.com/viewpdf-31152-elabscience-E-AB-11111.PDF