DCTN3 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. 
Research Areas: Cancer, Cell Biology, Signal transduction
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:100-1:300
Size: 200 uL
Concentration: 0.6mg/mL
Swissprot: O75935
Gene Accession: BC000319
Reactivity: Human
Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human DCTN3
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control: Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.
Cellular Localization: Cytoplasm. Cytoplasm>cytoskeleton>centrosome. Chromosome>centromere>kinetochore. Cytoplasm>cytoskeleton>spindle. Cleavage furrow. Midbody. Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-dctn3_polyclonal_antibody-31185.html
Manual Link: https://www.elabscience.com/viewpdf-31185-elabscience-E-AB-11144.PDF