Product Type: Antibody
Descritpion: Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Neuroscience, Signal transduction
Recommended Dilutions: WB 1:1000-1:5000, IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_003737
Immunogen: Recombinant protein of human DYNLL1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 10kDa
Tissue Specificity/Positive Control: Ubiquitous.
Cellular Localization: Cytoplasm, cytoskeleton. Nucleus. Mitochondrion. Upon induction of apoptosis translocates together with BCL2L11 to mitochondria.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-dynll1_polyclonal_antibody-31200.html
Manual Link: https://www.elabscience.com/viewpdf-31200-elabscience-E-AB-11159.PDF