Product Type: Antibody
Descritpion: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Research Areas: Cancer, Metabolism, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:50-1:200
Size: 200 uL
Gene Accession: BC001890
Immunogen: Recombinant protein of human GCK
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 52kDa
Tissue Specificity/Positive Control: Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.
Cellular Localization: Cytosol,Mitochondrion,Nucleus,nucleoplasm
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-gck_polyclonal_antibody-31301.html
Manual Link: https://www.elabscience.com/viewpdf-31301-elabscience-E-AB-11261.PDF