Product Type: Antibody
Descritpion: Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:50-1:200
Size: 200 uL
Gene Accession: BC003690
Immunogen: Recombinant protein of human IPO4
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 119kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytoplasm. Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-ipo4_polyclonal_antibody-31371.html
Manual Link: https://www.elabscience.com/viewpdf-31371-elabscience-E-AB-11331.PDF