Product Type: Antibody
Descritpion: This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.
Research Areas: Cancer, Cardiovascular, Metabolism, Immunology, Signal transduction, Stem cells
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Gene Accession: BC128168
Immunogen: Recombinant protein of human IRGM
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.
Cellular Localization: Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle>phagosome membrane. Cytoplasmic vesicle>autophagosome membrane. Cell projection>phagocytic cup. Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-irgm_polyclonal_antibody-31376.html
Manual Link: https://www.elabscience.com/viewpdf-31376-elabscience-E-AB-11336.PDF