OS9 Polyclonal AntibodyE-AB-11460
Product Type: Antibody
Descritpion: This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Gene Accession: BC007254
Immunogen: Recombinant protein of human OS9
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 76kDa
Tissue Specificity/Positive Control: Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma OSA-CL and rhabdomyosarcoma RH30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.
Cellular Localization: Endoplasmic reticulum lumen.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-os9_polyclonal_antibody-31500.html
Manual Link: https://www.elabscience.com/viewpdf-31500-elabscience-E-AB-11460.PDF