Product Type: Antibody
Descritpion: The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:500-1:2000, IHC 1:10-1:50
Size: 200 uL
Gene Accession: BC110585
Immunogen: Recombinant protein of human RNF20
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 114kDa
Tissue Specificity/Positive Control: Expressed in the normal brain and also in malignant gliomas (at protein level).
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-rnf20_polyclonal_antibody-31586.html
Manual Link: https://www.elabscience.com/viewpdf-31586-elabscience-E-AB-11546.PDF