Product Type: Antibody
Descritpion: This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.
Research Areas: Cancer, Signal transduction
Recommended Dilutions: IHC 1:30-1:150
Size: 200 uL
Gene Accession: BC015806
Immunogen: Recombinant protein of human SH3KBP1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Ubiquitously expressed. Also expressed in some cancer cell lines.
Cellular Localization: Cytoplasm>cytoskeleton. Cytoplasmic vesicle membrane. Cell junction>synapse>synaptosome. Cell junction>focal adhesion. Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-sh3kbp1_polyclonal_antibody-31618.html
Manual Link: https://www.elabscience.com/viewpdf-31618-elabscience-E-AB-11578.PDF