SRGAP3 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
Research Areas: Neuroscience, Signal transduction
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Concentration: 0.6mg/mL
Swissprot: O43295
Gene Accession: BC039300
Reactivity: Human,Mouse
Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human SRGAP3
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control: Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain.
Cellular Localization: Cytosol,Other locations:cytoplasm
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-srgap3_polyclonal_antibody-31640.html
Manual Link: https://www.elabscience.com/viewpdf-31640-elabscience-E-AB-11600.PDF