C4A (? chain) Polyclonal AntibodyE-AB-11634
Product Type: Antibody
Descritpion: C4A encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.C4A (Complement C4A (Rodgers Blood Group)) is a Protein Coding gene. Diseases associated with C4A include C4a Deficiency and Immunodeficiency Due To A Classical Component Pathway Complement Deficiency. Among its related pathways are Complement Pathway and Innate Immune System. GO annotations related to this gene include endopeptidase inhibitor activity and complement component C1q binding. An important paralog of this gene is C4B.
Research Areas: Immunology
Recommended Dilutions: WB 1:200-1:1000
Size: 200 uL
Immunogen: Synthetic peptide of human C4A (? chain)
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 75kDa
Tissue Specificity/Positive Control: Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland,and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response.1 Publication
Cellular Localization: Secreted
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-c4a_(?_chain)_polyclonal_antibody-39653.html
Manual Link: https://www.elabscience.com/viewpdf-39653-elabscience-E-AB-11634.PDF