FAT1 Polyclonal AntibodyE-AB-11636
Product Type: Antibody
Descritpion: This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction
Recommended Dilutions: WB 1:2000-1:5000
Size: 200 uL
Immunogen: Synthetic peptide of human FAT1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 50kDa
Tissue Specificity/Positive Control: Expressed in many epithelial and some endothelial and smooth muscle cells.
Cellular Localization: Cell membrane. Nucleus. Cytoplasm>perinuclear region.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-fat1_polyclonal_antibody-39655.html
Manual Link: https://www.elabscience.com/viewpdf-39655-elabscience-E-AB-11636.PDF