VGLL1 Polyclonal AntibodyE-AB-11655
Product Type: Antibody
Descritpion: The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. TDU interacted directly with the TEA domain family member, TEF1, and deletion of the Vg homology region abolished the interaction. The TDU-TEF1 dimer activated a reporter plasmid, and expression of TDU in Drosophila rescued loss of Vg function. The interaction was stronger in cardiac myocytes, suggesting a myocyte-specific factor may participate in the interaction. Vgll1 was weakly active in driving expression of a reporter gene from the mouse skeletal muscle alpha-actin promoter, and Vgll1 could partially reverse the inhibitory effect of TEF1 in this assay.
Research Areas: Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:2000-1:10000, IHC 1:25-100
Size: 200 uL
Gene Accession: NP_057351
Immunogen: Synthetic peptide of human VGLL1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 29kDa
Tissue Specificity/Positive Control:
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-vgll1_polyclonal_antibody-39674.html
Manual Link: https://www.elabscience.com/viewpdf-39674-elabscience-E-AB-11655.PDF