VNN1 Polyclonal AntibodyE-AB-11664
Product Type: Antibody
Descritpion: This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24.
Research Areas: Cell Biology, Cardiovascular, Metabolism, Signal transduction, Stem cells
Recommended Dilutions: IHC 1:50-100, IF/ICC 1:100-1:500
Size: 200 uL
Gene Accession: NP_004657
Immunogen: Synthetic peptide of human VNN1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.
Cellular Localization: Cell membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-vnn1_polyclonal_antibody-39683.html
Manual Link: https://www.elabscience.com/viewpdf-39683-elabscience-E-AB-11664.PDF