GAD2 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
Research Areas: Cancer, Metabolism, Neuroscience
Applications: WB
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Concentration: 1mg/mL
Swissprot: Q05329
Gene Accession:
Reactivity: Human
,Mouse

Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human GAD2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 65kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytoplasm>cytosol. Cytoplasmic vesicle. Cell junction>synapse>presynaptic cell membrane. Golgi apparatus membrane. Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-gad2_polyclonal_antibody-39717.html
Manual Link: https://www.elabscience.com/viewpdf-39717-elabscience-E-AB-11698.PDF