JAM-A Polyclonal AntibodyE-AB-11759
Product Type: Antibody
Descritpion: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as a receptor for reovirus, a ligand for the integrin LFA1, involved in leukocyte transmigration, and a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Research Areas: Cancer, Cardiovascular, Signal transduction
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Immunogen: Recombinant protein of human F11R
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 33kDa
Tissue Specificity/Positive Control: Expressed in endothelium, epithelium and leukocytes (at protein level).
Cellular Localization: Cell junction>tight junction. Cell membrane. Localized at tight junctions of both epithelial and endothelial cells.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-jam_a_polyclonal_antibody-39778.html
Manual Link: https://www.elabscience.com/viewpdf-39778-elabscience-E-AB-11759.PDF