SLC22A5 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants.
Research Areas: Metabolism, Signal transduction
Applications: WB
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Concentration: 0.3mg/mL
Swissprot: O76082
Gene Accession:
Reactivity: Human
,Mouse
,Rat

Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human SLC22A5
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 63kDa
Tissue Specificity/Positive Control: Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells.
Cellular Localization: Membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-slc22a5_polyclonal_antibody-39814.html
Manual Link: https://www.elabscience.com/viewpdf-39814-elabscience-E-AB-11795.PDF