TYK2 Polyclonal AntibodyE-AB-11864
Product Type: Antibody
Descritpion: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.TYK2 (Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with TYK2 include Immunodeficiency 35 and Primary Cutaneous Anaplastic Large Cell Lymphoma. Among its related pathways are Type I Interferon Signaling Pathways and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is JAK1.
Research Areas: Signal transduction
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Immunogen: Recombinant protein of human TYK2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 134kDa
Tissue Specificity/Positive Control: Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Cellular Localization: Cytoskeleton,Cytosol,Extracellular region or secreted,extracellular exosome,Nucleus,Plasma Membrane,extrinsic component of cytoplasmic side of plasma membrane,Other locations:cytoplasm
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-tyk2_polyclonal_antibody-39883.html
Manual Link: https://www.elabscience.com/viewpdf-39883-elabscience-E-AB-11864.PDF