Product Type: Antibody
Descritpion: Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.
Research Areas: Cancer, Immunology, Signal transduction, Tags & Cell Markers
Recommended Dilutions: WB 1:500-1:2000, IHC 1:50-100
Size: 200 uL
Immunogen: Synthetic peptide of human ZAP70 (Ab-319)
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 69kDa
Tissue Specificity/Positive Control: Expressed in T- and natural killer cells.
Cellular Localization: Cytoplasm. Cell membrane. After antigen stimulation, isoform 1 concentrates at the immunological synapse and isoform 2 remains cytoplasmic. Co-localizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes.
Storage: Store at -20C. Avoid freeze / thaw cycles.