RPS6KA5 Polyclonal AntibodyE-AB-12092
Product Type: Antibody
Descritpion: Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Immunogen: Synthetic peptide of human RPS6KA5 (Ab-376)
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 90kDa
Tissue Specificity/Positive Control: Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.
Cellular Localization: Nucleus. Cytoplasm. Predominantly nuclear. Partially cytoplasmic.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-rps6ka5_polyclonal_antibody-39933.html
Manual Link: https://www.elabscience.com/viewpdf-39933-elabscience-E-AB-12092.PDF