SNCA Polyclonal AntibodyE-AB-12103
Product Type: Antibody
Descritpion: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
Research Areas: Cancer, Neuroscience
Recommended Dilutions: WB 1:500-1:1000
Size: 200 uL
Immunogen: Synthetic peptide of human SNCA (Ab-125)
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 14kDa
Tissue Specificity/Positive Control: Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Cellular Localization: Cytoplasm, cytosol. Membrane. Nucleus. Cell junction, synapse. Secreted. Membrane-bound in dopaminergic neurons.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-snca_polyclonal_antibody-39944.html
Manual Link: https://www.elabscience.com/viewpdf-39944-elabscience-E-AB-12103.PDF