FGFR4 Polyclonal AntibodyE-AB-12147
Product Type: Antibody
Descritpion: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. FGFR4 (Fibroblast Growth Factor Receptor 4) is a Protein Coding gene. Diseases associated with FGFR4 include Prostate Cancer and Neuroma. Among its related pathways are GPCR Pathway and RET signaling. An important paralog of this gene is FGFR3.
Research Areas: Cancer, Cell Biology, Cardiovascular, Neuroscience, Signal transduction, Stem cells, Tags & Cell Markers
Recommended Dilutions: WB 1:500-1:1000
Size: 200 uL
Immunogen: Synthetic peptide of human FGFR4
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 88kDa
Tissue Specificity/Positive Control: Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
Cellular Localization: Membrane. Isoform 2 may be secreted.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-fgfr4_polyclonal_antibody-39988.html
Manual Link: https://www.elabscience.com/viewpdf-39988-elabscience-E-AB-12147.PDF