Product Type: Antibody
Descritpion: This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. Rab35 plays an important role in insulin-stimulated GLUT4 translocation in adipocytes.It is the target of TBC1D10A–C and that the intracellular accumulation of endosomal vesicles and impairs exosome secretion were occured when inhibition of Rab35 function.The surface of oligodendroglia in a GTP-dependent manner was localized Rab35, it increases the density of vesicles, and may have a function in docking or tethering.
Research Areas: Cell Biology, Signal transduction
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Gene Accession: NP_006852
Immunogen: Synthetic peptide of human RAB35
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control:
Cellular Localization: Cell membrane. Membrane>clathrin-coated pit. Cytoplasmic vesicle>clathrin-coated vesicle. Endosome. Melanosome. Present on sorting endosomes and endosomal tubules. Tends to be enriched in PIP2-positive cell membrane domains. During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-rab35_polyclonal_antibody-31693.html
Manual Link: https://www.elabscience.com/viewpdf-31693-elabscience-E-AB-12236.PDF