PPP1R13B Polyclonal AntibodyE-AB-12281
Product Type: Antibody
Descritpion: The protein plays a central role in regulation of apoptosis via its interaction with p53/TP53.Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.It contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins.
Research Areas: Cancer, Stem cells
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_056131
Immunogen: Synthetic peptide of human ASPP1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Reduced expression in breast carcinomas expressing a wild-type TP53 protein.
Cellular Localization: Cytoplasm. Nucleus. Predominantly cytoplasmic. Some fraction is nuclear.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-ppp1r13b_polyclonal_antibody-31737.html
Manual Link: https://www.elabscience.com/viewpdf-31737-elabscience-E-AB-12281.PDF