Product Type: Antibody
Descritpion: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
Research Areas: Cancer, Cell Biology, Metabolism, Signal transduction
Recommended Dilutions: WB 1:200-1:1000, IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_055232.1
Immunogen: Synthetic peptide of human BBC3
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 21kDa
Tissue Specificity/Positive Control: Ubiquitously expressed.
Cellular Localization: Mitochondrion. Localized to the mitochondria in order to induce cytochrome c release.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-bbc3_polyclonal_antibody-31745.html
Manual Link: https://www.elabscience.com/viewpdf-31745-elabscience-E-AB-12289.PDF