Product Type: Antibody
Descritpion: Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family. This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. CRMP1 mediates reelin signaling in cortical neuronal migration. Mice deficient in CRMP1 exhibit impaired long-term potentiation and impaired spatial learning and memory. CRMP1 gene overlaps with another gene called EVC. CRMP1 has been shown to interact with DPYSL2.
Research Areas: Cancer, Neuroscience, Signal transduction
Recommended Dilutions: WB 1:500-1:1000, IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_001304
Immunogen: Synthetic peptide of human CRMP1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 62kDa
Tissue Specificity/Positive Control: Brain.
Cellular Localization: Cytoplasm. Cytoplasm>cytoskeleton>centrosome. Cytoplasm>cytoskeleton>spindle. Associated with centrosomes and the mitotic spindle during metaphase.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-crmp1_polyclonal_antibody-31787.html
Manual Link: https://www.elabscience.com/viewpdf-31787-elabscience-E-AB-12333.PDF