CRMP1 Polyclonal Antibody
CRMP1 Polyclonal Antibody

CRMP1 Polyclonal Antibody


Regular price $399.00 $349.00 You Pay

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family. This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. CRMP1 mediates reelin signaling in cortical neuronal migration. Mice deficient in CRMP1 exhibit impaired long-term potentiation and impaired spatial learning and memory. CRMP1 gene overlaps with another gene called EVC. CRMP1 has been shown to interact with DPYSL2.
Research Areas: Cancer, Neuroscience, Signal transduction
Applications: WB,IHC,ELISA
Recommended Dilutions: WB 1:500-1:1000, IHC 1:25-1:100
Size: 200 uL
Concentration: 0.4mg/mL
Swissprot: Q14194
Gene Accession: NP_001304
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human CRMP1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 62kDa
Tissue Specificity/Positive Control: Brain.
Cellular Localization: Cytoplasm. Cytoplasm>cytoskeleton>centrosome. Cytoplasm>cytoskeleton>spindle. Associated with centrosomes and the mitotic spindle during metaphase.
Storage: Store at -20C. Avoid freeze / thaw cycles.

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