SFRP1 Polyclonal AntibodyE-AB-12387
Product Type: Antibody
Descritpion: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8.
Research Areas: Cancer, Cell Biology, Developmental biology, Neuroscience, Stem cells
Recommended Dilutions: IHC 1:10-1:50
Size: 200 uL
Gene Accession: NP_003003
Immunogen: Synthetic peptide of human SFRP1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes.
Cellular Localization: Secreted. Cell membrane or extracellular matrix-associated. Released by heparin-binding.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-sfrp1_polyclonal_antibody-31839.html
Manual Link: https://www.elabscience.com/viewpdf-31839-elabscience-E-AB-12387.PDF