Product Type: Antibody
Descritpion: The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
Research Areas: Cancer, Signal transduction, Tags & Cell Markers
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_002007
Immunogen: Synthetic peptide of human FLG
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Keratohyalin granules.
Cellular Localization: Cytoskeleton,intermediate filament,Cytosol,Nucleus,Plasma Membrane,cornified envelope,Other locations:intracellular membrane-bounded organelle,keratohyalin granule
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-flg_polyclonal_antibody-31861.html
Manual Link: https://www.elabscience.com/viewpdf-31861-elabscience-E-AB-12409.PDF