ID4 Polyclonal AntibodyE-AB-12434
Product Type: Antibody
Descritpion: DNA-binding protein inhibitor ID-4 is a protein that in humans is encoded by the ID4 gene. Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative (antimorph) HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins .
Research Areas: Epigenetics and Nuclear Signaling, Stem cells
Recommended Dilutions: IHC 1:20-1:100
Size: 200 uL
Gene Accession: NP_001537
Immunogen: Synthetic peptide of human ID4
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control:
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-id4_polyclonal_antibody-31886.html
Manual Link: https://www.elabscience.com/viewpdf-31886-elabscience-E-AB-12434.PDF