Product Type: Antibody
Descritpion: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
Research Areas: Cancer, Cell Biology, Metabolism, Neuroscience, Signal transduction
Recommended Dilutions: WB 1:200-1:1000, IHC 1:5-1:20
Size: 200 uL
Gene Accession: NP_000152
Immunogen: Synthetic peptide of human GCH1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 28kDa
Tissue Specificity/Positive Control: In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).
Cellular Localization: Cytoplasm. Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-gch1_polyclonal_antibody-31945.html
Manual Link: https://www.elabscience.com/viewpdf-31945-elabscience-E-AB-12496.PDF