LRP5 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.
Research Areas: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal transduction, Stem cells
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Concentration: 0.6mg/mL
Swissprot: O75197
Gene Accession: NP_002326
Reactivity: Human,Mouse
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human LRP5
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control: Widely expressed, with the highest level of expression in the liver.
Cellular Localization: Membrane. Endoplasmic reticulum. Chaperoned to the plasma membrane by MESD.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-lrp5_polyclonal_antibody-31991.html
Manual Link: https://www.elabscience.com/viewpdf-31991-elabscience-E-AB-12546.PDF