Product Type: Antibody
Descritpion: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
Research Areas: Cancer, Neuroscience, Signal transduction, Stem cells, Tags & Cell Markers
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_001139280
Immunogen: Synthetic peptide of human ITGAM
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Predominantly expressed in monocytes and granulocytes.
Cellular Localization: Membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-cd11b_polyclonal_antibody-31996.html
Manual Link: https://www.elabscience.com/viewpdf-31996-elabscience-E-AB-12551.PDF